Fish Oil
Omega-3 marine
triglycerides are considered to be essential fatty acids - they are essential
for human health, but cannot be manufactured by the body. It is therefore
necessary to obtain these acids from food, with fish (particularly fatty fish
such as salmon, tuna, herring and mackerel) providing an excellent source.
Due to the extra strain placed on
weight-bearing joints, obese individuals are at a significantly higher risk of
developing osteoarthritis. Studies have proven the omega-3 fish oils EPA and
DHA to inhibit the production of pro-inflammatory substances (cytokines)
responsible for the inflammation and gradual cartilage degradation caused by
arthritis. In recent years, these studies have been supported by a considerable
number of clinical trials in which patients suffering from the effects of
arthritis have experienced significant improvements in outcome measures such as
tender joints, morning stiffness, grip strength and the interval to fatigue
onset.
Evidence has emerged for a protective
effect for fish oils against cardiovascular diseases, with eicosapentaenoic
acid having been shown to reduce the likelihood of major coronary events in
patients prone to heart disease. Studies have also shown fish oil
supplementation to mediate positive effects on length of gestation and possibly
child visual and cognitive development during pregnancy.
Vitamin E
Vitamin E is widely regarded as the most
biologically active antioxidant in the human body. Through its ability to
inhibit the oxidation of LDL-cholesterol ("bad cholesterol"), higher intakes of
vitamin E have been linked with a lowered incidence of artherosclerosis and
other related cardiovascular diseases in several large scale population
studies.
Studies have also suggested that
insufficient vitamin E intake during pregnancy may increase the risk of
complications such as pre-eclampsia and babies being born underweight.
Acetyl
L-Carnitine
Acetyl l-carnitine is a naturally synthesised amino acid produced
in the body by the kidneys, liver and brain and present at high concentrations
in skeletal and cardiac muscle. Acetyl l-carnitine plays an important role in
lipid metabolism, assisting in the oxidation of long-chain fatty acids by
transporting them from across the mitochondrial membrane in their esterified
form. In doing so, acetyl l-carnitine is thought to help facilitate glucose
metabolism. This function has been supported by recent studies, in which tissue
glucose uptake in healthy volunteers administered acetyl l-carnitine was
significantly improved.
Folic Acid (Folate)
Obese women face a significantly higher risk of experiencing
complications during pregnancy. Regular supplementation with folate during
pregnancy is associated with a decreased risk of infants being born with neural
tube defects. Folate is also important for the production of myelin, which acts
as an insulating sheath for neurons (nerve cells) and is essential for the
transduction of messages throughout the nervous system.
Studies have also provided evidence for the crucial role of folate
in the conversion of homocysteine to methionine and tetrahydrofolate, both of
which are essential for the DNA synthesis and subsequent production of red
blood cells (erythrocytes).